Tiziano Barbui # 1 , Valerio De Stefano # 2 , Alessandra Carobbio 3 , Alessandra Iurlo 4 , Alberto Alvarez-Larran 5 , Beatriz Cuevas 6 , Francisca Ferrer Marín 7 , Alessandro M Vannucchi 8 , Francesca Palandri 9 , Claire Harrison 10 , Hassan Sibai 11 , Martin Griesshammer 12 , Massimiliano Bonifacio 13 , Elena M Elli 14 , Chiara Trotti 15 ...Feb 22, 2023 · Graveyard of Shadows. A second place you can find green dragons in Old School RuneScape is just north of the Graveyard of Shadows, which itself is just north of the Ferox Enclave. There are five dragons in this location. This is a nice location due to its proximity to the Ferox Enclave, which is a safe settlement within the Wilderness. Angelina Jolie will star in Oscar-nominated director Pablo Larraín’s next movie, a biopic about famous opera singer Maria Callas. Titled “Maria,” the film “tells the tumultuous, beautiful ...just checked, the minimum for each key is 400k but the highest i see is 450k. 4. Spixican • 1 yr. ago. Wow that is a pricey key. I wouldn't had guessed that much. I have a newfound appreciation to Larran keys. I already loved them but now even more! 4. Past-Boat-755 • 1 yr. ago.Larran's key is a key obtained from killing monsters while on a Slayer task given by Krystilia. It is used to open Larran's small and big chests. The exact odds of receiving a key scales with the monster's Combat level. For levels 1-80, the probability follows a curve between 1/1972 at level 1 to 1/100 at level 80.The exp is far faster, many of the tasks are fully afk-able, the loot is fantastic,and I'm drowning in slayer points. It's so afk even when 3 iteming that I can afk most tasks in my phone and simply check the loot every couple minutes. If I get a larran's key I teleport out and come back. The efficacy of danazol was assessed in 50 patients with myelofibrosis and anemia using the recently revised criteria of the International Working Group for Myelofibrosis Research and Treatment. According to them, anemia response (clinical improvement) is defined as transfusion cessation in transfus …24291. The Dagon'hai robe top is a piece of magic armour obtained as a rare loot from Larran's big chest. It is part of the Dagon'hai robes set, and requires level 70 Magic and 40 Defence to wear. It can be stored in a magic wardrobe in a player owned house. Attack bonuses.Therapeutic options for patients with polycythemia vera (PV) and essential thrombocythemia (ET) resistant or intolerant to hydroxyurea are limited. Busulfan is effective as first-line therapy, but there is scarce information on this drug as second-line treatment. The efficacy of busulfan in patients …Graveyard of Shadows. A second place you can find green dragons in Old School RuneScape is just north of the Graveyard of Shadows, which itself is just north of the Ferox Enclave. There are five dragons in this location. This is a nice location due to its proximity to the Ferox Enclave, which is a safe settlement within the Wilderness.8699. Larran is a non-player character found north-east of the Chaos Temple by his small chest . If players speak to him while wearing a ghostspeak amulet, they will learn that he was once a wealthy merchant who stored his possessions in a small and big chest in the Wilderness, where he believed few would attempt to open them.24291. The Dagon'hai robe top is a piece of magic armour obtained as a rare loot from Larran's big chest. It is part of the Dagon'hai robes set, and requires level 70 Magic and 40 Defence to wear. It can be stored in a magic wardrobe in a player owned house. Attack bonuses.Fue de los primeros en Salta, luego llegaron otros, incluso con más pisos y otra muestra de arquitectura moderna, pero fue el monoblock Salta el que cumplió el expreso pedido del gobierno de 1960: “levantar una obra que quede como símbolo”. Así lo expresa el creador de esta estructura, el arquitecto Eduardo Larrán, en una entrevista de ...Larran Wade Walls is 66 years old and lives in Oxford, Georgia. Larran has 3 different addresses, the most recent of which is in Oxford, Georgia. Associated Addresses. 45 Highlands Forest Ln, Oxford, GA 300543300 Groveland Way, Antelope, CA 958433704 Coco Ln, North Highlands, CA 95660. Associated Phone Numbers.Larran's key is a key obtained from killing monsters while on a Slayer task given by Krystilia. It is used to open Larran's small and big chests. The exact odds of receiving a key scales with the monster's Combat level. For levels 1-80, the probability follows a curve between 1/1972 at level 1 to 1/100 at level 80. The Home Depot Pro Specialty Trades, formerly Leran Gas Products, is becoming HD Supply. That means one-stop convenience and access to the essential supplies, resources, and tools that your business demands. We are here to help make your job easier, and are still your single-source supplier for everything from gas products and electrical ...Doing 10 hours of Wilderness Slayer at the new Wilderness Slayer Caves to see how the new Larrans key boost effects the drop table and pk anyone in our way. ...Larran, Inc in Fenton, MO received a Paycheck Protection Loan of $137,615 through Midwest BankCentre, which was approved in April, 2020. This loan's status is reported by the SBA as "Paid in Full", which includes both loans repaid and those fully forgiven from repayment under PPP guidelines. The loan's status was last updated by the SBA in ...Larran's big chest has an expected value of 2k more than what the key sells for on GE. HOWEVER that also assumes you are hitting the droprate for dagonhai. You could get lucky and pull two tops and come out wildly ahead or you could go 300 dry and come out wildly behind. Personally, I'd just sell them. DevoidHT • 14 days ago.Larran's Chests & Keys Every monster in the wilderness drops the Larran's key, the higher the monsters HP the higher the chance that it drops it. It has a chance of rewarding the Dagon' hai robes, upon a reward of 25M+ it will be broadcasted to the entire server so be aware!The clinical significance of resistance/intolerance to hydroxycarbamide (HC) was assessed in a series of 890 patients with polycythaemia vera (PV). Resistance/intolerance to HC was recorded in 137 patients (15·4%), consisting of: need for phlebotomies (3·3%), uncontrolled myeloproliferation (1·6%), …The optimal duration of treatment with vitamin K antagonists (VKA) after venous thromboembolism (VTE) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) is uncertain. To tackle this issue, we retrospectively studied 206 patients with MPN-related VTE (deep venous thrombosis of …Jun 8, 2020 · Larran's Chests & Keys Every monster in the wilderness drops the Larran's key, the higher the monsters HP the higher the chance that it drops it. It has a chance of rewarding the Dagon' hai robes, upon a reward of 25M+ it will be broadcasted to the entire server so be aware! Larran is a high school graduate. 45 Highlands Forest La, Oxford, GA 30054-3046 is the last known address for Larran. Seven persons linked to this address. Their names are Courtney Jones, Joshua Jones, and five others. Larran uses the landline number (770) 787-7980 (Bellsouth Telecommunications, LLC).Ruxolitinib is better than other available therapies in achieving hematocrit control and symptom relief in patients with polycythemia vera who are resistant/intolerant to hydroxyurea, but we still do not know whether ruxolitinib provides an additional benefit in preventing thrombosis or disease prog …Padre Pablo. 27,091 likes · 1,150 talking about this. Public figureLarran's key is a key obtained from killing monsters while on a Slayer task given by Krystilia. It is used to open Larran's small and big chests. The exact odds of receiving a key scales with the monster's Combat level. For levels 1-80, the probability follows a curve between 1/1972 at level 1 to 1/100 at level 80.The lesser demon is the sixth strongest monster in free-to-play, only beaten by the ankous in the Stronghold of Security, the level 85 skeletons, greater demons in the Wilderness, and the bosses Obor and Bryophyta . Safespot location for lesser demons in Chasm of Fire. The Chasm of Fire is one of the best locations for slaying lesser demons. Pablo Larraín Matte ( Spanish pronunciation: [laraˈin]) is a Chilean filmmaker. He is known for films such as the Academy Award -nominated films No (2012), Neruda (2016), Jackie (2016), and Spencer (2021).Buying larrans keys! : r/2007scape. 13 comments. Best. Add a Comment. RS_Complain • 1 yr. ago. FYI keys are currently selling for 450K per key in the collection log discord. whypvmersmadge • 1 yr. ago. You're ruining the mans merching attempt. Lazy_Inferno. Larran's key is a key obtained from killing monsters while on a Slayer task given by Krystilia. It is used to open Larran's small and big chests. The exact odds of receiving a key scales with the monster's Combat level. For levels 1-80, the probability follows a curve between 1/1972 at level 1 to 1/100 at level 80. The big larran's key chest is basically a safezone LOL! : r/2007scape. Good job jagex. The big larran's key chest is basically a safezone LOL! You just go 2 steps north of the chest up to the ladder and you end up in a 1x1 spot where a pker can not even attack you at. High risk high reward hu?? This isnt new.. LORAN, short for long range navigation, [a] was a hyperbolic radio navigation system developed in the United States during World War II. It was similar to the UK's Gee system but operated at lower frequencies in order to provide an improved range up to 1,500 miles (2,400 km) with an accuracy of tens of miles. Objective: Erythropoiesis-stimulating agents (ESAs) are commonly used to treat the anemia of myelofibrosis (MF), but information on the predictors of response is limited.Recommendations regarding management of essential thrombocythaemia rely on studies done before the discovery of the CALR mutation. On May 20, 2020, the European LeukemiaNet annual meeting was held with the goal to identify unmet clinical needs in myeloproliferative neoplasms. Because patients with a …Clinical characteristics, prognosis and treatment of myelofibrosis patients with severe thrombocytopenia Recombinant human erythropoietin (rHuEPO) is an effective treatment for the anaemia that occurs secondary to various conditions, but its role in myelofibrosis with myeloid metaplasia (MMM) is not well established. rHuEPO, at an initial dose of 10 000 U thrice a week, was given to 20 patients with MM …The clinical significance of resistance/intolerance to hydroxycarbamide (HC) was assessed in a series of 890 patients with polycythaemia vera (PV). Resistance/intolerance to HC was recorded in 137 patients (15·4%), consisting of: need for phlebotomies (3·3%), uncontrolled myeloproliferation (1·6%), …Feb 4, 2021 · Tiziano Barbui 1 , Valerio De Stefano 2 , Alberto Alvarez-Larran 3 , Alessandra Iurlo 4 , Arianna Masciulli 5 , Alessandra Carobbio 5 , Arianna Ghirardi 5 , Alberto Ferrari 5 , Valeria Cancelli 6 , Elena Maria Elli 7 , Marcio Miguel Andrade-Campos 8 , Mercedes Gasior Kabat 9 , Jean-Jaques Kiladjian 10 , Francesca Palandri 11 , Giulia Benevolo ... Therapeutic options for patients with polycythemia vera (PV) and essential thrombocythemia (ET) resistant or intolerant to hydroxyurea are limited. Busulfan is effective as first-line therapy, but there is scarce information on this drug as second-line treatment. The efficacy of busulfan in patients … The exp is far faster, many of the tasks are fully afk-able, the loot is fantastic,and I'm drowning in slayer points. It's so afk even when 3 iteming that I can afk most tasks in my phone and simply check the loot every couple minutes. If I get a larran's key I teleport out and come back. The Home Depot Pro Specialty Trades, formerly Leran Gas Products, is becoming HD Supply. That means one-stop convenience and access to the essential supplies, resources, and tools that your business demands. We are here to help make your job easier, and are still your single-source supplier for everything from gas products and electrical ... County Executive. Office of the County Executive. 1550 Franklin Avenue. Mineola, NY 11501. 516-571-3131. Thank you! Nice! and again thanks for helping me out! Everything went smoothly and OP traded the money afterwards. Sold him 8 keys, he went first. No problems would do again! Just so everyone knows, this guy is legit. Paid me 500k per key and was quick and easy. He gave me half first, the other half after.We assessed the benefit/risk of low-dose aspirin in 433 patients with low-risk essential thrombocythemia (271 with a CALR mutation, 162 with a JAK2 (V617F) mutation) who were on antiplatelet therapy or observation only. After a follow up of 2215 person-years free from cytoreduction, 25 thrombotic and 17 bleeding episodes were recorded.Therapeutic options for patients with polycythemia vera (PV) and essential thrombocythemia (ET) resistant or intolerant to hydroxyurea are limited. Busulfan is effective as first-line therapy, but there is scarce information on this drug as second-line treatment. The efficacy of busulfan in patients …The expert panel agreed on 33 statements, reflecting a consensus, which will guide clinical decision making for patients with hematological neoplasms during the COVID-19 pandemic. Angelina Jolie will star in Oscar-nominated director Pablo Larraín’s next movie, a biopic about famous opera singer Maria Callas. Titled “Maria,” the film “tells the tumultuous, beautiful ...Larran moved to River Point Dr in Mcdonough, Georgia, 30252-4148 in 2022 and has been living at this address ever since. What are Larran Walls’s previous home addresses? Larran is known to have lived at the following address: 45 Highlands Forest Ln, Oxford, GA, 30054-3046 .- Because Larran's Keys are always lost on death, suiciding to have time in the Wilderness without risking everything would have meant losing the keys. In order to circumvent this, you'd have to travel to Larran's big chest and cash in any keys you have (probably 1 or 2 most of the time) before suiciding again. Become an outstanding merchant - Register today. Join 601.8k+ other OSRS players who are already capitalising on the Grand Exchange. Check out our OSRS Flipping Guide (2023), covering GE mechanics, flip finder tools and price graphs. The exp is far faster, many of the tasks are fully afk-able, the loot is fantastic,and I'm drowning in slayer points. It's so afk even when 3 iteming that I can afk most tasks in my phone and simply check the loot every couple minutes. If I get a larran's key I teleport out and come back.An icon used to represent a menu that can be toggled by interacting with this icon. Current Guide Price 134.3k. Today's Change - 2,154 - 1%. 1 Month Change - 34.4k - 20%. 3 Month Change 48.8k + 57%.• social responsibility • ethics Laraine Day (born La Raine Johnson, October 13, 1920 – November 10, 2007) was an American actress, radio and television commentator, and former Metro-Goldwyn-Mayer (MGM) contract star. As a leading lady, she was paired opposite major film stars, including Robert Mitchum, Lana Turner, Cary Grant, Ronald Reagan, Kirk Douglas, and John Wayne.When the Music Stopped: Directed by Russ Mayberry. With Carroll O'Connor, Howard E. Rollins Jr., Alan Autry, Anne-Marie Johnson. A washed up country singer, whose biggest fan is Bubba Skinner, is accused of the murder of his former road manager.Nov 26, 2021 · The “Goodfellas” star recently joined her costars Michael Imperioli and Steve Schirripa on their podcast “Talking Sopranos” and reflected on her annoyance with her character’s exit. “I ... The lesser demon is the sixth strongest monster in free-to-play, only beaten by the ankous in the Stronghold of Security, the level 85 skeletons, greater demons in the Wilderness, and the bosses Obor and Bryophyta . Safespot location for lesser demons in Chasm of Fire. The Chasm of Fire is one of the best locations for slaying lesser demons.Larran moved to River Point Dr in Mcdonough, Georgia, 30252-4148 in 2022 and has been living at this address ever since. What are Larran Walls’s previous home addresses? Larran is known to have lived at the following address: 45 Highlands Forest Ln, Oxford, GA, 30054-3046 .Larran's small chest can be found north-east of the Chaos Temple. The chest is locked and can only be opened by using Larran's key, which is obtained from killing monsters that Krystilia assigns the player. Loot awarded to the player by opening the chest is around 30% less than that of Larran's big chest, and gives no chance at Dagon'hai robes.Lauren Jbara Salary. Jbara receives an average salary ranging from $24,292 to $72,507. This translates to an hourly average wage of between $10.15 and $31.32. Her actual salary figures are under review and will be updated soon when disclosed to the public.Juan-Carlos Hernández-Boluda 1 , Arturo Pereira 2 , Alberto Alvarez-Larran 3 , Ana-Africa Martín 4 , Ana Benzaquen 5 , Lourdes Aguirre 6 , Elvira Mora 7 , Pedro González 8 , Jorge Mora 9 , Nieves Dorado 10 , Antonia Sampol 11 , Valentín García-Gutiérrez 12 , Oriana López-Godino 13 , María-Laura Fox 14 , Juan Luis Reguera 15 , Manuel ...Jun 8, 2020 · Larran's Chests & Keys Every monster in the wilderness drops the Larran's key, the higher the monsters HP the higher the chance that it drops it. It has a chance of rewarding the Dagon' hai robes, upon a reward of 25M+ it will be broadcasted to the entire server so be aware! Graveyard of Shadows. A second place you can find green dragons in Old School RuneScape is just north of the Graveyard of Shadows, which itself is just north of the Ferox Enclave. There are five dragons in this location. This is a nice location due to its proximity to the Ferox Enclave, which is a safe settlement within the Wilderness.Fundamentos de contabilidad financiera: Teoría y práctica. Fundamentos de contabilidad financiera. : Manuel Larrán Jorge. Ediciones Pirámide, 2008 - Business & Economics - 416 pages. El objetivo de esta obra es sentar las bases conceptuales y técnicas de la contabilidad financiera a partir de un enfoque teórico-práctico, lo que ... Larran's Chest Needs to be More Rewarding. When you put it in context, the Larran's Keys are supposed to be part of a Wilderness Rejuvenation effort that's goal is make/update content that will entice more players to use the Wilderness. It sounds great; tons of potential to creatively reward players willing to train in the wildy, as well as re ...The crystal key is created by combining a tooth half of key with a loop half of key, displaying the message, "You join the two halves of the key together." Key halves can be obtained as rewards from Barrows, the Gnome Restaurant minigame, Managing Miscellania, Treasure Trails, looting magpie implings, random events, the rare drop table, spoils of war, etc. The efficacy of danazol was assessed in 50 patients with myelofibrosis and anemia using the recently revised criteria of the International Working Group for Myelofibrosis Research and Treatment. According to them, anemia response (clinical improvement) is defined as transfusion cessation in transfus …The lesser demon is the sixth strongest monster in free-to-play, only beaten by the ankous in the Stronghold of Security, the level 85 skeletons, greater demons in the Wilderness, and the bosses Obor and Bryophyta . Safespot location for lesser demons in Chasm of Fire. The Chasm of Fire is one of the best locations for slaying lesser demons. Jun 8, 2020 · Larran's Chests & Keys Every monster in the wilderness drops the Larran's key, the higher the monsters HP the higher the chance that it drops it. It has a chance of rewarding the Dagon' hai robes, upon a reward of 25M+ it will be broadcasted to the entire server so be aware! GoFundMe. Three men who spent the past 24 years behind bars for the double slaying of an off-duty NYPD cop and Queens businessman were ordered freed from prison Friday — after a judge ruled they ...Oct 1, 2017 · In the last 30 years, different economic, political and social changes have taken place in the university sector and this has led to an extensive reform to meet the new societal challenges that these institutions are facing today. This emphasises the social dimension of universities and their important role in society as educators of future leaders and policy makers. This reveals the need to ... Ruxolitinib is better than other available therapies in achieving hematocrit control and symptom relief in patients with polycythemia vera who are resistant/intolerant to hydroxyurea, but we still do not know whether ruxolitinib provides an additional benefit in preventing thrombosis or disease prog …Need A New Computer/Laptop? Use Code "nosleep5" for 5% off ALL IronSide products! Benefits me a ton.https://ironsidecomputers.com/mintmadcow channel - https:...Currently working as a postdoc researcher at the Center for Research in Agricultural Genomics (CRAG) in Spain. My research line is focused on the mechanisms controlling epigenetic silencing in plants. Sep 17, 2019 · Larran's Key Buffs: Bolts/ Arrows- I'm completely fine with this +1; Cerberus Boots- Maybe just dragon boots (or) or something not Cerberus boots -1; Dominion Tower gloves- Again this isn't necessary -1; Remove Godswords- I kind of like the variety and ease of getting the lesser used Godswords and each of them have a place in terms of ... Juan-Carlos Hernández-Boluda 1 , Arturo Pereira 2 , Alberto Alvarez-Larran 3 , Ana-Africa Martín 4 , Ana Benzaquen 5 , Lourdes Aguirre 6 , Elvira Mora 7 , Pedro González 8 , Jorge Mora 9 , Nieves Dorado 10 , Antonia Sampol 11 , Valentín García-Gutiérrez 12 , Oriana López-Godino 13 , María-Laura Fox 14 , Juan Luis Reguera 15 , Manuel ... Hindrigo "Kiko" Lorran was the chef on Below Deck Mediterranean season 5 and continues to live out his dream as a professional chef to this day. During his time on the show, Kiko was able to develop close relationships with his crew members, especially Chief Steward Hannah Ferrier. Kiko may have been friendly with the crew, but his cooking did ...Thinking of names? Complete 2021 information on the meaning of Larran, its origin, history, pronunciation, popularity, variants and more as a baby boy name. Fue de los primeros en Salta, luego llegaron otros, incluso con más pisos y otra muestra de arquitectura moderna, pero fue el monoblock Salta el que cumplió el expreso pedido del gobierno de 1960: “levantar una obra que quede como símbolo”. Así lo expresa el creador de esta estructura, el arquitecto Eduardo Larrán, en una entrevista de ...Thank you! Nice! and again thanks for helping me out! Everything went smoothly and OP traded the money afterwards. Sold him 8 keys, he went first. No problems would do again! Just so everyone knows, this guy is legit. Paid me 500k per key and was quick and easy. He gave me half first, the other half after.18. Report. Share. Posted November 5, 2021 (edited) Absolutely not. At least not at the current prices. Averages out to about 3700 per key (after reduction of overall price because nothing sells for "actual value") So if you want to risk it all to make a few hundred pkp per key, be my guest lol. Just get asked a lot if keys are profitable so ...
Thank you! Nice! and again thanks for helping me out! Everything went smoothly and OP traded the money afterwards. Sold him 8 keys, he went first. No problems would do again! Just so everyone knows, this guy is legit. Paid me 500k per key and was quick and easy. He gave me half first, the other half after. . Katara camping d art
Myelofibrosis (MF) is a clonal myeloproliferative neoplasm, typically associated with disease-related symptoms, splenomegaly, cytopenias and bone marrow fibrosis. Patients experience a significant symptom burden and a reduced life expectancy. Patients with MF receive ruxolitinib as the current stand …The optimal duration of treatment with vitamin K antagonists (VKA) after venous thromboembolism (VTE) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) is uncertain. To tackle this issue, we retrospectively studied 206 patients with MPN-related VTE (deep venous thrombosis of … An icon used to represent a menu that can be toggled by interacting with this icon.Pablo Larraín was born in Santiago, Chile. He is a director, writer and producer, known for Spencer (2021), Jackie (2016), El Club (2015), NO (2012), among others. Together with his brother Juan de Dios Larraín, they founded Fabula in 2004, one of the most prolific production companies in Latin America. More at IMDbPro. Contact info. Agent info.Angelina Jolie will star in Oscar-nominated director Pablo Larraín’s next movie, a biopic about famous opera singer Maria Callas. Titled “Maria,” the film “tells the tumultuous, beautiful ...Buying larrans keys! : r/2007scape. 13 comments. Best. Add a Comment. RS_Complain • 1 yr. ago. FYI keys are currently selling for 450K per key in the collection log discord. whypvmersmadge • 1 yr. ago. You're ruining the mans merching attempt. Lazy_Inferno.Larran's key is a key obtained from killing monsters while on a Slayer task given by Krystilia. It is used to open Larran's small and big chests. The exact odds of receiving a key scales with the monster's Combat level. For levels 1-80, the probability follows a curve between 1/1972 at level 1 to 1/100 at level 80.Nov 23, 2021 · Haemolysis of serum samples is the leading cause of preanalytical errors in clinical laboratories. Little is known about the potential alterations in the concentrations of mineral elements in haemolyzed serum and the phenomenon has not been specifically studied in bovine serum samples. We investigat … Fundamentos de contabilidad financiera: Teoría y práctica. Fundamentos de contabilidad financiera. : Manuel Larrán Jorge. Ediciones Pirámide, 2008 - Business & Economics - 416 pages. El objetivo de esta obra es sentar las bases conceptuales y técnicas de la contabilidad financiera a partir de un enfoque teórico-práctico, lo que ...Recombinant human erythropoietin (rHuEPO) is an effective treatment for the anaemia that occurs secondary to various conditions, but its role in myelofibrosis with myeloid metaplasia (MMM) is not well established. rHuEPO, at an initial dose of 10 000 U thrice a week, was given to 20 patients with MM …Graveyard of Shadows. A second place you can find green dragons in Old School RuneScape is just north of the Graveyard of Shadows, which itself is just north of the Ferox Enclave. There are five dragons in this location. This is a nice location due to its proximity to the Ferox Enclave, which is a safe settlement within the Wilderness.Larran's key is a key obtained from killing monsters while on a Slayer task given by Krystilia. It is used to open Larran's small and big chests. The exact odds of receiving a key scales with the monster's Combat level. For levels 1-80, the probability follows a curve between 1/1972 at level 1 to 1/100 at level 80..